9/21/2023 0 Comments Cbtricks modulacao positiva no vr![]() ![]() Multivariate analysis based on the Cox regression modelshowed that the factors associated with a low risk of death were youngerage, high DLCO/alveolar volume, IPF, and high COX-1 expression in alveolarsepta, whereas those associated with a high risk of death were advanced age,low DLCO/alveolar volume, SSc (with NSIP), and low COX-1 expression inalveolar septa. Nodifference was found between IPF-UIP and SSc-NSIP tissue regarding COX-1 andCOX-2 expression. The expression of COX-1 and COX-2 in alveolar septa was significantly higherin IPF-UIP and SSc-NSIP lung tissue than in the control tissue. We thencorrelated that expression with pulmonary function test results andevaluated its impact on patient survival. We usedimmunohistochemistry and histomorphometry to evaluate the expression ofCOX-1 and COX-2 in alveolar septa, vessels, and bronchioles. The histological patternsincluded fibrotic nonspecific interstitial pneumonia (NSIP) in SSc patientsand usual interstitial pneumonia (UIP) in IPF patients. We examined open lung biopsy specimens from 24 SSc patients and 30 IPFpatients, using normal lung tissue as a control. To study the expression of COX-1 and COX-2 in the remodeled lung in systemicsclerosis (SSc) and idiopathic pulmonary fibrosis (IPF) patients,correlating that expression with patient survival. ![]() This article has been cited by other articles in PMC. ![]()
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